Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043642 | 0.86 | MAPT (0.52) | MAPTHTTLMNASMN1; SMN2GAA | |
| SCHEMBL8050309 | 0.86 | ALDH1A1 (0.44) | MAPTHTTLMNASMN1; SMN2GAA | |
| SCHEMBL8042199 | 0.86 | ALPG (0.46) | MAPTHTTLMNAHPGDPDK1 | |
| SCHEMBL8043944 | 0.86 | MAPT (0.54) | MAPTHTTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8045042 | 0.81 | NPSR1 (0.46) | MAPTHTTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8042679 | 0.81 | MAPK8 (0.43) | MAPTHTTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8710810 | 0.80 | MAPT (0.50) | MAPTHTTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8048212 | 0.79 | PDK1 (0.48) | MAPTHTTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8047056 | 0.79 | TSHR (0.48) | MAPTHTTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8051667 | 0.79 | PDK1 (0.48) | MAPTHTTLMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |