Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050831 | 0.87 | HSP90AA1 (0.46) | KMT2ATSHRMEN1HSP90AA1HSP90AB1 | |
| SCHEMBL8047245 | 0.85 | KDM4E (0.54) | KMT2ATSHRMEN1HSP90AA1HSP90AB1 | |
| SCHEMBL8043169 | 0.84 | HSP90AA1 (0.46) | KMT2ATSHRMEN1HSP90AA1HSP90AB1 | |
| SCHEMBL8042284 | 0.83 | TSHR (0.56) | KMT2ATSHRMEN1HSP90AA1HSP90AB1 | |
| SCHEMBL8048024 | 0.83 | TSHR (0.43) | KMT2ATSHRMEN1HSP90AA1HSP90AB1 | |
| SCHEMBL8046525 | 0.80 | TSHR (0.49) | KMT2ATSHRMEN1KDM4EGAA | |
| SCHEMBL8032454 | 0.80 | TSHR (0.49) | KMT2ATSHRMEN1KDM4EGAA | |
| SCHEMBL8043590 | 0.80 | KDM4E (0.53) | KMT2ATSHRMEN1KDM4EGAA | |
| SCHEMBL8047456 | 0.79 | MEN1 (0.47) | KMT2ATSHRMEN1KDM4EGAA | |
| SCHEMBL8047465 | 0.78 | NPSR1 (0.47) | KMT2ATSHRMEN1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |