Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8047456 | 0.89 | MEN1 (0.47) | TSHRMEN1KMT2AKDM4EGAA | |
| SCHEMBL8044904 | 0.86 | TSHR (0.41) | TSHRMEN1KMT2AKDM4EHTT | |
| SCHEMBL8043590 | 0.83 | KDM4E (0.53) | TSHRMEN1KMT2AKDM4EGAA | |
| SCHEMBL8047245 | 0.83 | KDM4E (0.54) | TSHRMEN1KMT2AKDM4EGAA | |
| SCHEMBL8044219 | 0.83 | TSHR (0.38) | TSHRMEN1KMT2AKDM4EGAA | |
| SCHEMBL8044988 | 0.82 | KDM4E (0.58) | TSHRMEN1KMT2AKDM4EMIF | |
| SCHEMBL8042595 | 0.82 | RAB9A (0.47) | TSHRMEN1KMT2AKDM4EGAA | |
| SCHEMBL8045928 | 0.81 | TSHR (0.52) | TSHRMEN1KMT2AKDM4EGAA | |
| SCHEMBL8042833 | 0.80 | KMT2A (0.48) | TSHRMEN1KMT2AKDM4EGAA | |
| SCHEMBL8032454 | 0.80 | TSHR (0.49) | TSHRMEN1KMT2AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |