Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043767 | 0.87 | KDM4E (0.49) | KDM4EGAAGLAHTTTSHR | |
| SCHEMBL8045928 | 0.85 | TSHR (0.52) | KDM4EGAAGLAHTTTSHR | |
| SCHEMBL8048230 | 0.85 | KDM4E (0.43) | KDM4EGAAGLAHTTTSHR | |
| SCHEMBL8033836 | 0.84 | TSHR (0.47) | KDM4EGAAGLAHTTTSHR | |
| SCHEMBL8047188 | 0.84 | MEN1 (0.53) | KDM4EGAAGLAHTTTSHR | |
| SCHEMBL8046525 | 0.83 | TSHR (0.49) | KDM4EGAAGLAHTTTSHR | |
| SCHEMBL8047245 | 0.83 | KDM4E (0.54) | KDM4EGAAGLAHTTTSHR | |
| SCHEMBL8045082 | 0.82 | MEN1 (0.45) | KDM4EGAAGLAHTTTSHR | |
| SCHEMBL8033238 | 0.81 | RAB9A (0.52) | KDM4EGAAHTTTSHRMEN1 | |
| SCHEMBL8032454 | 0.81 | TSHR (0.49) | KDM4EGAAGLAHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |