SCHEMBL8043011

SCHEMBL8043011

O=[N+]([O-])c1cc(C(F)(F)F)c(F)cc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.47
ATM Q13315 1/20 0.47
ALDH1A1 P00352 4/20 0.46
HIF1A Q16665 2/20 0.46
CYP3A4 P08684 3/20 0.44
ALOX15 P16050 2/20 0.44
TSHR P16473 2/20 0.44
HPGD P15428 1/20 0.44
TXNRD1 Q16881 1/20 0.44
TXNRD3 Q86VQ6 1/20 0.44
TXNRD2 Q9NNW7 1/20 0.44
VCAM1 P19320 1/20 0.43
ESPL1 Q14674 1/20 0.42
PTGES O14684 3/20 0.41
TTR P02766 1/20 0.39
SIRT6 Q8N6T7 1/20 0.39
AR P10275 2/20 0.38
LMNA P02545 2/20 0.38
HTT P42858 2/20 0.38
CES2 O00748 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31510262 1.00 TDP1 (0.47) TDP1ATMALDH1A1HIF1ACYP3A4
SCHEMBL30568358 0.86 PTGES (0.46) TDP1ATMALDH1A1HIF1ACYP3A4
SCHEMBL29704389 0.83 TDP1 (0.43) TDP1ATMALDH1A1HIF1ACYP3A4
SCHEMBL602315 0.83 TDP1 (0.43) TDP1ATMALDH1A1HIF1ACYP3A4
SCHEMBL29739489 0.83 TDP1 (0.43) TDP1ATMALDH1A1HIF1ACYP3A4
SCHEMBL1770903 0.83 ALDH1A1 (0.49) TDP1ATMALDH1A1HIF1ACYP3A4
SCHEMBL1192979 0.83 ALDH1A1 (0.49) TDP1ATMALDH1A1HIF1ACYP3A4
SCHEMBL4648762 0.83 TDP1 (0.43) TDP1ATMALDH1A1HIF1ACYP3A4
SCHEMBL16729388 0.83 ALDH1A1 (0.42) TDP1ATMALDH1A1HIF1ACYP3A4
SCHEMBL29267943 0.83 ALDH1A1 (0.49) TDP1ATMALDH1A1HIF1ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6121264-A GLUTAMATE RECEPTOR ANTAGONIST, AMPA RECEPTOR ANTAGONIST, NMDA-GLYCINE RECEPTOR ANTAGONIST, KAINIC ACID NEUROTOXICITY INHIBITOR, ANTIISCHEMIC AGENT, PSYCHOTROPIC AGENT YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 2000-09-19 US disclosed
US-6096743-A 1,2,3,4-tetrahydroquinoxalinedione derivative YAMANOUCHI PHARMACEUTICALS CO., LTD. (JP) 2000-08-01 US disclosed
EP-0993461-A1 NEW QUINOXALINE DIONE DERIVATIVES, THE PRODUCTION THEREOF AND USE OF THE SAME IN MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 2000-04-19 EP disclosed
EP-0919554-A1 IMIDAZOLE-SUBSTITUTED QUINOXALINEDIONE DERIVATIVES YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1999-06-02 EP disclosed
WO-1999000384-A1 NEW QUINOXALINE DIONE DERIVATIVES, THE PRODUCTION THEREOF AND USE OF THE SAME IN MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 1999-01-07 WO disclosed
EP-0784054-A1 1,2,3,4-TETRAHYDROQUINOXALINEDIONE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1997-07-16 EP disclosed
EP-0698024-B1 [1,2,4]TRIAZOLO [4,3-a]QUINOXALINE COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK AS (DK) 1997-01-22 EP disclosed
US-5532236-A TREATMENT OF PARKINSON'S DISEASE NOVO NORDISK A/S (DK) 1996-07-02 US disclosed
WO-1996012725-A1 NOVEL QUINOXALINDIONE DERIVATIVES, THEIR PRODUCTION AND USE IN MEDICAMENTS SCHERING AKTIENGESELLSCHAFT (DE) 1996-05-02 WO disclosed
EP-0698024-A1 1,2,4]TRIAZOLO 4,3-a]QUINOXALINE COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK AS (DK) 1996-02-28 EP disclosed
WO-1994026746-A1 [1,2,4]TRIAZOLO[4,3-a]QUINOXALINE COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1994-11-24 WO disclosed