Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TNKS | O95271 | 5/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8038367 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2MAPTNPC1RAB9ANFKB1 | |
| SCHEMBL8032664 | 0.76 | CNR2 (0.42) | SMN1; SMN2MAPTNPC1RAB9ANFKB1 | |
| SCHEMBL8034245 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2TNKSTNKS2PARP2ERCC1 | |
| SCHEMBL8036853 | 0.76 | SIRT2 (0.54) | TNKSTNKS2PARP2SIRT2SIRT1 | |
| SCHEMBL8022486 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2TNKSTNKS2PARP2ERCC1 | |
| SCHEMBL8032162 | 0.74 | SIRT2 (0.52) | TNKSTNKS2PARP2SIRT2SIRT1 | |
| SCHEMBL8040669 | 0.74 | NPSR1 (0.42) | SMN1; SMN2MAPTNPC1RAB9ANFKB1 | |
| SCHEMBL8031508 | 0.74 | ATM (0.46) | SMN1; SMN2MAPTNPC1RAB9ANFKB1 | |
| SCHEMBL8041741 | 0.73 | NPSR1 (0.42) | SMN1; SMN2MAPTNPC1RAB9ANFKB1 | |
| SCHEMBL8024878 | 0.73 | NAMPT (0.40) | SMN1; SMN2MAPTNPC1RAB9ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080242-A1 | SUBSTITUTED 4-AMINOPYRIMIDINE-5-CARBOXYLIC ACID AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080248-A1 | SUBSTITUTED 2-PHENYLPYRIMIDINE-5-CARBOXYLIC ACIDS AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-07-02 | — | — | WO | disclosed |