Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048229 | 0.89 | F2 (0.40) | MEN1ALDH1A1MAPTHTTRAB9A | |
| SCHEMBL8050250 | 0.88 | ALDH1A1 (0.34) | MEN1ALDH1A1MAPTHTTRAB9A | |
| SCHEMBL8042342 | 0.84 | PTGS1 (0.33) | MEN1ALDH1A1MAPTHTTRAB9A | |
| SCHEMBL8033002 | 0.82 | PTGS1 (0.33) | ALDH1A1PTGS1PTGS2GAA | |
| SCHEMBL8047168 | 0.82 | APEX1 (0.33) | GAAL3MBTL1 | |
| SCHEMBL8046531 | 0.82 | PTGS1 (0.32) | PTGS1PTGS2 | |
| SCHEMBL8032336 | 0.80 | PTGS1 (0.32) | PTGS1PTGS2 | |
| SCHEMBL8710461 | 0.79 | MEN1 (0.35) | MEN1ALDH1A1MAPTHTTRAB9A | |
| SCHEMBL8042604 | 0.79 | ALDH1A1 (0.35) | ALDH1A1PTGS1PTGS2 | |
| SCHEMBL8043938 | 0.79 | POLB (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |