Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | GFER | P55789 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | GAA | P10253 | 6/20 | 0.47 |
| ▸ | EP300 | Q09472 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051779 | 0.88 | ALDH1A1 (0.47) | ALDH1A1GFERPOLBL3MBTL1MEN1 | |
| SCHEMBL8033095 | 0.88 | ALDH1A1 (0.52) | ALDH1A1GFERPOLBL3MBTL1MEN1 | |
| SCHEMBL8044411 | 0.86 | KMT2A (0.55) | ALDH1A1POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL8044961 | 0.86 | MEN1 (0.44) | ALDH1A1GFERPOLBL3MBTL1MEN1 | |
| SCHEMBL8032508 | 0.86 | MAPT (0.52) | ALDH1A1POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL8033820 | 0.85 | ALDH1A1 (0.49) | ALDH1A1GFERPOLBL3MBTL1MEN1 | |
| SCHEMBL8042553 | 0.82 | HPGD (0.48) | ALDH1A1POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL8043014 | 0.82 | RECQL (0.49) | ALDH1A1POLBMEN1KMT2AHPGD | |
| SCHEMBL8048432 | 0.82 | MEN1 (0.47) | ALDH1A1POLBL3MBTL1MEN1KMT2A | |
| SCHEMBL8051869 | 0.80 | ALDH1A1 (0.45) | ALDH1A1POLBL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |