Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8052304 | 0.89 | ALDH1A1 (0.49) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8033820 | 0.88 | ALDH1A1 (0.49) | RECQLMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8048328 | 0.87 | PKM (0.41) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8033160 | 0.87 | PKM (0.51) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8044961 | 0.87 | MEN1 (0.44) | RECQLMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8032424 | 0.87 | PKM (0.45) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8045105 | 0.86 | ALDH1A1 (0.40) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8035046 | 0.86 | PTGS2 (0.53) | MEN1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8050176 | 0.86 | PTGS2 (0.53) | MEN1KMT2AALDH1A1HPGDRXFP1 | |
| SCHEMBL8050410 | 0.85 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |