Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032107 | 0.88 | HIF1A (0.45) | HIF1ALMNASMN1; SMN2KDM4EMITF | |
| SCHEMBL8041619 | 0.88 | HIF1A (0.47) | HIF1ALMNASMN1; SMN2KDM4EMITF | |
| SCHEMBL8042355 | 0.87 | HIF1A (0.47) | HIF1ALMNASMN1; SMN2KDM4EMITF | |
| SCHEMBL8041606 | 0.86 | HIF1A (0.51) | HIF1ALMNASMN1; SMN2KDM4EMITF | |
| SCHEMBL8045505 | 0.86 | HIF1A (0.45) | HIF1ALMNASMN1; SMN2KDM4EMITF | |
| SCHEMBL8049621 | 0.86 | HIF1A (0.44) | HIF1ALMNASMN1; SMN2KDM4EMITF | |
| SCHEMBL8041620 | 0.86 | HIF1A (0.48) | HIF1ALMNASMN1; SMN2KDM4EMITF | |
| SCHEMBL8032100 | 0.85 | HIF1A (0.43) | HIF1ALMNASMN1; SMN2KDM4EMITF | |
| SCHEMBL8043531 | 0.82 | METAP1 (0.49) | HIF1ALMNASMN1; SMN2KDM4EMITF | |
| SCHEMBL8043550 | 0.82 | CYP1A2 (0.49) | HIF1ALMNASMN1; SMN2KDM4EMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |