Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049599 | 0.91 | CYP1A2 (0.57) | CYP1A2CYP2C9CYP2C19L3MBTL1ALDH1A1 | |
| SCHEMBL8045505 | 0.83 | HIF1A (0.45) | SMN1; SMN2TRPV1KDM4ELMNAHIF1A | |
| SCHEMBL8032107 | 0.83 | HIF1A (0.45) | SMN1; SMN2TRPV1KDM4ELMNAHIF1A | |
| SCHEMBL8043588 | 0.82 | HIF1A (0.43) | ALDH1A1SMN1; SMN2MAPK1NPSR1TRPV1 | |
| SCHEMBL8045497 | 0.82 | TRPV1 (0.44) | CYP1A2SMN1; SMN2KMT2ATRPV1KDM4E | |
| SCHEMBL8043558 | 0.81 | TRPV1 (0.46) | CYP1A2ALDH1A1SMN1; SMN2TRPV1KDM4E | |
| SCHEMBL8041606 | 0.81 | HIF1A (0.51) | SMN1; SMN2KDM4EMAPTLMNAHIF1A | |
| SCHEMBL8049621 | 0.81 | HIF1A (0.44) | SMN1; SMN2TRPV1KDM4ELMNAHIF1A | |
| SCHEMBL8041620 | 0.80 | HIF1A (0.48) | SMN1; SMN2TRPV1KDM4ELMNAHIF1A | |
| SCHEMBL8041619 | 0.79 | HIF1A (0.47) | L3MBTL1SMN1; SMN2MAPK1TRPV1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |