Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042356 | 0.92 | HIF1A (0.50) | METAP1MAPTHIF1AGRM5SMN1; SMN2 | |
| SCHEMBL8041617 | 0.92 | MAPT (0.47) | METAP1MAPTHIF1AGRM5SMN1; SMN2 | |
| SCHEMBL8041606 | 0.91 | HIF1A (0.51) | METAP1MAPTHIF1AGRM5SMN1; SMN2 | |
| SCHEMBL8032085 | 0.89 | HIF1A (0.52) | METAP1MAPTHIF1ASMN1; SMN2HTT | |
| SCHEMBL8042355 | 0.88 | HIF1A (0.47) | METAP1MAPTHIF1AGRM5SMN1; SMN2 | |
| SCHEMBL8032107 | 0.87 | HIF1A (0.45) | HIF1AGRM5SMN1; SMN2KDM4ELMNA | |
| SCHEMBL8043507 | 0.86 | NPC1 (0.43) | MAPTHIF1AGRM5SMN1; SMN2KDM4E | |
| SCHEMBL8043558 | 0.85 | TRPV1 (0.46) | HIF1AGRM5SMN1; SMN2KDM4ELMNA | |
| SCHEMBL8045505 | 0.85 | HIF1A (0.45) | METAP1HIF1AGRM5SMN1; SMN2KDM4E | |
| SCHEMBL8049571 | 0.85 | OPRK1 (0.49) | MAPTHIF1AGRM5SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |