Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 9/20 | 0.39 |
| ▸ | HPGD | P15428 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045096 | 0.80 | PDPK1 (0.51) | KDM4EALDH1A1KMT2AMEN1FBP1 | |
| SCHEMBL8048142 | 0.78 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10EPHX2RAB9A | |
| SCHEMBL8042588 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1HSD17B10EPHX2RAB9A | |
| SCHEMBL8050088 | 0.75 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10EPHX2RAB9A | |
| SCHEMBL8052069 | 0.74 | RAB9A (0.60) | KDM4EALDH1A1HSD17B10EPHX2RAB9A | |
| SCHEMBL8050726 | 0.74 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10EPHX2RAB9A | |
| SCHEMBL11991177 | 0.74 | KDM4E (0.73) | KDM4EALDH1A1HSD17B10EPHX2RAB9A | |
| SCHEMBL8046537 | 0.73 | MAPK8 (0.57) | KDM4EALDH1A1HSD17B10EPHX2RAB9A | |
| SCHEMBL8050078 | 0.73 | KDM4E (0.40) | KDM4EALDH1A1HSD17B10EPHX2RAB9A | |
| SCHEMBL4648 | 0.72 | PDPK1 (0.56) | KDM4EALDH1A1HSD17B10EPHX2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |