Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 6/20 | 0.41 |
| ▸ | CA2 | P00918 | 6/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | CA4 | P22748 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042210 | 0.86 | TSHR (0.47) | TSHRHSD17B10KDM4EPTGS2PTGS1 | |
| SCHEMBL8036965 | 0.85 | TSHR (0.67) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8046885 | 0.84 | TSHR (0.49) | TSHRHSD17B10KDM4EPTGS2PTGS1 | |
| SCHEMBL8050042 | 0.84 | HSD17B10 (0.49) | TSHRHSD17B10KDM4EPTGS2PTGS1 | |
| SCHEMBL8045030 | 0.84 | KDM4E (0.49) | TSHRHSD17B10KDM4EPTGS2PTGS1 | |
| SCHEMBL8044388 | 0.84 | TSHR (0.53) | TSHRHSD17B10KDM4EPTGS2ALDH1A1 | |
| SCHEMBL8033666 | 0.83 | PTGS2 (0.45) | TSHRHSD17B10KDM4EPTGS2PTGS1 | |
| SCHEMBL8046500 | 0.82 | HSD17B10 (0.54) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8043830 | 0.82 | TSHR (0.45) | TSHRHSD17B10KDM4EPTGS2PTGS1 | |
| SCHEMBL8038014 | 0.82 | TSHR (0.51) | TSHRHSD17B10KDM4EPTGS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |