Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 7/20 | 0.42 |
| ▸ | CA2 | P00918 | 7/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 6/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045522 | 0.88 | PKM (0.44) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8045952 | 0.87 | TSHR (0.59) | TSHRHSD17B10KDM4EALDH1A1USP2 | |
| SCHEMBL8042290 | 0.86 | CA1 (0.42) | TSHRHSD17B10KDM4EALDH1A1USP2 | |
| SCHEMBL8051758 | 0.86 | CA2 (0.47) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8043594 | 0.85 | TSHR (0.43) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8046636 | 0.85 | HSD17B10 (0.49) | TSHRHSD17B10KDM4EALDH1A1USP2 | |
| SCHEMBL8033666 | 0.84 | PTGS2 (0.45) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8033031 | 0.84 | HSD17B10 (0.49) | TSHRHSD17B10KDM4EALDH1A1USP2 | |
| SCHEMBL8042210 | 0.83 | TSHR (0.47) | TSHRHSD17B10KDM4EALDH1A1MAPK1 | |
| SCHEMBL8032481 | 0.83 | HSD17B10 (0.51) | TSHRHSD17B10KDM4EALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |