Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.49 |
| ▸ | TACR1 | P25103 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | RBP4 | P02753 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036182 | 0.85 | CACNA1B (0.58) | HSD11B1THRBRBP4CNR1SMN1; SMN2 | |
| SCHEMBL8048367 | 0.83 | EPHX2 (0.50) | HSD11B1RBP4GRIN2BEPHX2LMNA | |
| SCHEMBL8032644 | 0.80 | PDK2 (0.45) | RBP4EPHX2ALDH1A1LMNA | |
| SCHEMBL8050179 | 0.77 | TACR1 (0.44) | TACR1RBP4CNR1EPHX2 | |
| SCHEMBL348554 | 0.74 | HSD11B1 (0.69) | HSD11B1 | |
| SCHEMBL8041484 | 0.74 | CACNA2D1 (0.51) | MEN1KMT2AEPHX2 | |
| SCHEMBL8044223 | 0.73 | EPHX2 (0.43) | HSD11B1RBP4GRIN2BEPHX2ALDH1A1 | |
| SCHEMBL8041122 | 0.72 | MGLL (0.49) | HSD11B1MEN1KMT2ACNR1EPHX2 | |
| SCHEMBL3038927 | 0.71 | CACNA1B (0.51) | HSD11B1KMT2ACNR1TSHR | |
| SCHEMBL16936413 | 0.70 | HSD11B1 (0.69) | HSD11B1MEN1KMT2ACNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009045382-A1 | SUBSTITUTED ARYL SULFONE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | disclosed |