Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048048 | 0.86 | HSD17B10 (0.43) | SMN1; SMN2RAB9AUSP2ALDH1A1HSD17B10 | |
| SCHEMBL8046376 | 0.86 | SMN1; SMN2 (0.41) | SMN1; SMN2RAB9AUSP2ALDH1A1HSD17B10 | |
| SCHEMBL8048029 | 0.86 | TSHR (0.42) | SMN1; SMN2RAB9AUSP2ALDH1A1HSD17B10 | |
| SCHEMBL8050258 | 0.86 | ALDH1A1 (0.49) | SMN1; SMN2RAB9AUSP2ALDH1A1HSD17B10 | |
| SCHEMBL8042598 | 0.84 | TSHR (0.42) | SMN1; SMN2RAB9AUSP2ALDH1A1HSD17B10 | |
| SCHEMBL8033244 | 0.83 | TSHR (0.46) | SMN1; SMN2RAB9AUSP2ALDH1A1HSD17B10 | |
| SCHEMBL8045952 | 0.83 | TSHR (0.59) | SMN1; SMN2RAB9AUSP2ALDH1A1HSD17B10 | |
| SCHEMBL8041910 | 0.82 | TSHR (0.45) | SMN1; SMN2RAB9AUSP2ALDH1A1HSD17B10 | |
| SCHEMBL8042514 | 0.81 | TSHR (0.46) | RAB9AUSP2ALDH1A1HSD17B10TSHR | |
| SCHEMBL8033987 | 0.81 | ALDH1A1 (0.40) | SMN1; SMN2RAB9AUSP2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |