Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | APLNR | P35414 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051920 | 0.88 | TSHR (0.51) | SMN1; SMN2USP2RAB9ACSNK1DALDH1A1 | |
| SCHEMBL8043995 | 0.86 | SMN1; SMN2 (0.53) | SMN1; SMN2USP2RAB9AALDH1A1HSD17B10 | |
| SCHEMBL8050258 | 0.86 | ALDH1A1 (0.49) | SMN1; SMN2USP2RAB9AALDH1A1HSD17B10 | |
| SCHEMBL8048048 | 0.85 | HSD17B10 (0.43) | SMN1; SMN2USP2RAB9AALDH1A1HSD17B10 | |
| SCHEMBL8044955 | 0.84 | USP2 (0.48) | SMN1; SMN2USP2RAB9ACSNK1DALDH1A1 | |
| SCHEMBL8051273 | 0.84 | TSHR (0.42) | SMN1; SMN2USP2RAB9ACSNK1DALDH1A1 | |
| SCHEMBL8045522 | 0.84 | PKM (0.44) | SMN1; SMN2RAB9ACSNK1DALDH1A1HSD17B10 | |
| SCHEMBL8043947 | 0.83 | TSHR (0.44) | SMN1; SMN2USP2RAB9AALDH1A1HSD17B10 | |
| SCHEMBL8044959 | 0.82 | TSHR (0.45) | SMN1; SMN2RAB9ACSNK1DALDH1A1HSD17B10 | |
| SCHEMBL8044199 | 0.82 | TSHR (0.41) | SMN1; SMN2USP2RAB9ACSNK1DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |