SCHEMBL8044384

SCHEMBL8044384

S=P(Cl)(OCc1ccccc1)OCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.52
IDO1 P14902 1/20 0.44
AGXT P21549 1/20 0.43
ALDH1A1 P00352 2/20 0.42
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA9 Q16790 2/20 0.41
CA12 O43570 1/20 0.41
SRC P12931 1/20 0.40
CETP P11597 3/20 0.40
LMNA P02545 2/20 0.38
CYP1A2 P05177 1/20 0.38
PTGS1 P23219 1/20 0.38
SLC6A2 P23975 1/20 0.38
CYP2C19 P33261 1/20 0.38
PTGS2 P35354 1/20 0.38
SLC6A3 Q01959 1/20 0.38
HIF1A Q16665 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
NR4A1 P22736 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11419361 0.86 TSHR (0.52) TSHRIDO1AGXTALDH1A1CA1
SCHEMBL18279927 0.81 TSHR (0.56) TSHRIDO1AGXTALDH1A1CA1
SCHEMBL8044389 0.78 TSHR (0.48) TSHRIDO1AGXTALDH1A1CA1
SCHEMBL3068400 0.77 TSHR (0.63) TSHRIDO1AGXTALDH1A1CA1
SCHEMBL85540 0.77 TSHR (0.63) TSHRIDO1AGXTALDH1A1CA1
SCHEMBL1491036 0.77 TSHR (0.52) TSHRIDO1AGXTALDH1A1CA1
SCHEMBL698590 0.77 TSHR (0.63) TSHRIDO1AGXTALDH1A1CA1
SCHEMBL3068595 0.77 TSHR (0.52) TSHRIDO1AGXTALDH1A1CA1
SCHEMBL1491990 0.77 TSHR (0.63) TSHRIDO1AGXTALDH1A1CA1
SCHEMBL10691592 0.76 TSHR (0.50) TSHRIDO1AGXTCA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6018067-A UPGRADING A CRUDE DIHYDROCARBYLTHIOPHOSPHATE PRODUCT CONTAMINATED WITH A DIHYDROCARBYLPOLYSULFIDE AND/OR A DIHYDROCARBYLCHLOROPHOSPHATE, BY TREATING WITH HYPOCHLORITE SOLUTION AND SEPARATING AN AQUEOUS PHASE FROM THE PRODUCT ALBEMARLE CORPORATION (US) 2000-01-25 US disclosed
US-5955626-A Process of purifying dihydrocarbylchlorothiophosphates ALBEMARLE CORPORATION (US) 1999-09-21 US disclosed