Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042389 | 0.82 | TSHR (0.57) | SMN1; SMN2HTTMEN1KMT2AMAPK1 | |
| SCHEMBL8710522 | 0.82 | TP53 (0.46) | SMN1; SMN2POLBHTTMEN1KMT2A | |
| SCHEMBL8044387 | 0.82 | TSHR (0.37) | POLBMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL8042581 | 0.81 | ATM (0.47) | ATMSMN1; SMN2POLBHTTMEN1 | |
| SCHEMBL8052238 | 0.81 | POLB (0.45) | ATMSMN1; SMN2POLBHTTMEN1 | |
| SCHEMBL8044722 | 0.80 | RPA1 (0.45) | SMN1; SMN2MEN1KMT2AMAPK1TSHR | |
| SCHEMBL8045179 | 0.80 | TSHR (0.33) | MEN1KMT2AMAPK1TSHRALDH1A1 | |
| SCHEMBL8046377 | 0.79 | ALDH1A1 (0.47) | SMN1; SMN2HTTTSHRALDH1A1NPC1 | |
| SCHEMBL8032969 | 0.79 | SIRT2 (0.45) | ATMSMN1; SMN2POLBHTTMEN1 | |
| SCHEMBL8051030 | 0.78 | HTT (0.43) | ATMSMN1; SMN2HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |