Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044593 | 0.83 | ALPG (0.42) | TSHRCYP3A4KMT2AALDH1A1HTT | |
| SCHEMBL8712945 | 0.83 | TP53 (0.51) | TP53TSHRCYP3A4CYP2C19CNR2 | |
| SCHEMBL8044406 | 0.82 | ATM (0.44) | TSHRKMT2AALDH1A1HTTNPC1 | |
| SCHEMBL8046022 | 0.81 | TP53 (0.45) | TP53TSHRCYP3A4CYP2C19CNR2 | |
| SCHEMBL8042389 | 0.81 | TSHR (0.57) | TSHRCYP3A4CYP2C19KMT2AALDH1A1 | |
| SCHEMBL8044387 | 0.80 | TSHR (0.37) | TSHRKMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8044722 | 0.78 | RPA1 (0.45) | TSHRKMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8045179 | 0.78 | TSHR (0.33) | TP53TSHRKMT2AALDH1A1MAPK1 | |
| SCHEMBL8046377 | 0.78 | ALDH1A1 (0.47) | TSHRCYP3A4CYP2C19ALDH1A1HTT | |
| SCHEMBL8051559 | 0.78 | KDM4E (0.45) | TP53TSHRCYP3A4CYP2C19CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |