Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044562 | 0.86 | PTGS2 (0.76) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL8055955 | 0.82 | PTGS2 (0.63) | PTGS2PTGS1NR1H2SMN1; SMN2 | |
| SCHEMBL6724132 | 0.79 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8055954 | 0.78 | PTGS2 (0.64) | PTGS2PTGS1NR1H2NR1H3 | |
| SCHEMBL12326172 | 0.78 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL6243674 | 0.78 | KCNH2 (0.50) | PTGS2NR1H2NR1H3 | |
| SCHEMBL14019058 | 0.78 | ABL1 (0.56) | PTGS2PTGS1NR1H2 | |
| SCHEMBL7500687 | 0.77 | PTGS2 (0.67) | PTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL403698 | 0.77 | ADORA2A (0.55) | PTGS2PTGS1SMN1; SMN2LMNAACLY | |
| SCHEMBL29375895 | 0.77 | ADORA2A (0.55) | PTGS2PTGS1SMN1; SMN2LMNAACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794942-B1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-05-31 | — | — | EP | claimed |