Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043982 | 0.86 | ALDH1A1 (0.47) | EP300SMN1; SMN2ALDH1A1LMNATP53 | |
| SCHEMBL8051728 | 0.86 | CA1 (0.44) | — | |
| SCHEMBL8049019 | 0.82 | RECQL (0.47) | EP300SMN1; SMN2ALDH1A1LMNATP53 | |
| SCHEMBL8047493 | 0.82 | CYP1A2 (0.40) | EP300SMN1; SMN2ALDH1A1LMNATP53 | |
| SCHEMBL8048302 | 0.81 | KMT2A (0.39) | EP300SMN1; SMN2ALDH1A1LMNATP53 | |
| SCHEMBL8050392 | 0.81 | EP300 (0.44) | KEAP1NFE2L2EP300SMN1; SMN2LIMK1 | |
| SCHEMBL8042019 | 0.80 | ALDH1A1 (0.39) | EP300SMN1; SMN2ALDH1A1LMNATP53 | |
| SCHEMBL8048227 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL8046748 | 0.80 | RECQL (0.39) | EP300SMN1; SMN2ALDH1A1LMNATP53 | |
| SCHEMBL8044600 | 0.79 | EP300 (0.46) | KEAP1NFE2L2EP300SMN1; SMN2LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |