Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048506 | 0.90 | GAA (0.40) | KMT2AMEN1GAACYP1A2CYP2C9 | |
| SCHEMBL8032357 | 0.85 | AKR1B1 (0.44) | KMT2AMEN1GAATDP1HTT | |
| SCHEMBL8051381 | 0.84 | LMNA (0.42) | KMT2AMEN1GAATDP1HTT | |
| SCHEMBL8048077 | 0.83 | MAPT (0.51) | KMT2AMEN1HSD17B10USP2GAA | |
| SCHEMBL3446775 | 0.82 | GAA (0.49) | KMT2AMEN1HSD17B10USP2GAA | |
| SCHEMBL8047450 | 0.82 | HSP90AA1 (0.44) | KMT2AMEN1HSD17B10USP2GAA | |
| SCHEMBL8045797 | 0.80 | HSP90AA1 (0.45) | KMT2AMEN1GAATDP1HTT | |
| SCHEMBL8042070 | 0.80 | LMNA (0.43) | KMT2AMEN1GAATDP1HTT | |
| SCHEMBL8041694 | 0.79 | HSP90AA1 (0.49) | KMT2AMEN1GAATDP1HTT | |
| SCHEMBL8032726 | 0.79 | LMNA (0.40) | KMT2AMEN1HSD17B10GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |