SCHEMBL8045407

SCHEMBL8045407

CC(C)CCCC1CCC(CCc2ccc(-c3ccc(OC(F)(F)F)c(F)c3)cc2)CC1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 2/20 0.39
NAAA Q02083 2/20 0.37
CTSK P43235 1/20 0.37
EPHX2 P34913 4/20 0.37
FFAR4 Q5NUL3 1/20 0.35
HCRTR1 O43613 1/20 0.34
HCRTR2 O43614 1/20 0.34
GRM2 Q14416 1/20 0.34
CHRM2 P08172 2/20 0.34
CHRM5 P08912 2/20 0.34
CYP17A1 P05093 1/20 0.34
PDE2A O00408 1/20 0.34
TMEM97 Q5BJF2 1/20 0.34
SIGMAR1 Q99720 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34
SLC7A5 Q01650 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8048334 0.90 KCNH2 (0.40) KCNH2NAAACTSKEPHX2FFAR4
SCHEMBL8033992 0.89 KCNH2 (0.38) KCNH2NAAACTSKEPHX2HCRTR1
SCHEMBL8046214 0.88 KCNH2 (0.43) KCNH2EPHX2HCRTR1HCRTR2CHRM2
SCHEMBL8034372 0.88 FFAR4 (0.34) FFAR4CHRM2CHRM5CHRM1CHRM3
SCHEMBL8748046 0.88 RARB (0.39) NAAACTSKEPHX2FFAR4HCRTR1
SCHEMBL8049112 0.87 CTSK (0.37) KCNH2NAAACTSKEPHX2GRM2
SCHEMBL8747985 0.87 RARB (0.41) NAAACTSKEPHX2FFAR4HCRTR1
SCHEMBL8034592 0.86 EPHX2 (0.38) KCNH2NAAACTSKEPHX2FFAR4
SCHEMBL8748030 0.86 RARB (0.43) NAAACTSKEPHX2FFAR4HCRTR1
SCHEMBL8747918 0.86 RARB (0.43) NAAACTSKEPHX2FFAR4HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0733692-B1 Liquid crystalline compound, liquid crystal composition containing the same, and display device CHISSO CORP (JP) 2000-06-14 EP disclosed
US-5714088-A TRIFLUOROMETHYL- OR -METHOXYPHENYL-SUBSTITUTED BRANCHED ALKYL-SUBSTITUTED CYCLOHEXANES; LARGE POSITIVE VALUE OF DIELECTRIC ANISOTROPY; VERY LOW VISCOSITY; HIGH VOLTAGE HOLDING RATIO(SPECIFIC RESISTANCE); UV STABILITY CHISSO CORPORATION (JP) 1998-02-03 US disclosed
EP-0733692-A1 Liquid crystalline compound, liquid crystal composition containing the same, and display device Chisso Corporation (JP) 1996-09-25 EP disclosed