Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | P2RY6 | Q15077 | 8/20 | 0.45 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.45 |
| ▸ | NT5E | P21589 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | P2RY2 | P41231 | 4/20 | 0.37 |
| ▸ | P2RY4 | P51582 | 4/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8038432 | 0.78 | TAS1R3 (0.39) | NT5EPOLBMEN1KMT2ANPC1 | |
| SCHEMBL8038969 | 0.77 | ABL1 (0.59) | ABL1RIN1P2RY6P2RY14NT5E | |
| SCHEMBL8041901 | 0.76 | P2RY12 (0.41) | P2RY6NT5EP2RY2 | |
| SCHEMBL14429053 | 0.73 | P2RY6 (0.57) | ABL1RIN1P2RY6P2RY14NT5E | |
| SCHEMBL2527032 | 0.73 | P2RY6 (0.45) | ABL1RIN1P2RY6P2RY14NT5E | |
| SCHEMBL14429200 | 0.72 | POLB (0.47) | ABL1RIN1P2RY6P2RY14NT5E | |
| SCHEMBL14429054 | 0.71 | P2RY6 (0.52) | ABL1RIN1P2RY6P2RY14NT5E | |
| SCHEMBL14429240 | 0.71 | POLB (0.63) | ABL1RIN1P2RY6P2RY14NT5E | |
| SCHEMBL14429064 | 0.71 | POLB (0.63) | ABL1RIN1P2RY6P2RY14NT5E | |
| SCHEMBL14429247 | 0.71 | POLB (0.63) | ABL1RIN1P2RY6P2RY14NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6084082-A | SOLID PHASE SYNTHESIS BY ATTACHING BETA-LACTAM HAVING NUCLEOBASE TO SOLID SUPPORT, DEPROTECTING HYDROXY GROUP, REACTING FREE HYDROXYL GROUP WITH BETA-LACTAMTIDE HAVING ACTIVATED PHOSPHITE GROUP, AND OXIDIZING | ISIS PHARMACEUTICALS, INC. (US) | 2000-07-04 | — | — | US | disclosed |
| US-5866691-A | Lactam nucleic acids | ISIS PHARMACEUTICALS, INC. (US) | 1999-02-02 | — | — | US | disclosed |
| US-5554746-A | Lactam nucleic acids | ISIS PHARMACEUTICALS, INC. (US) | 1996-09-10 | — | — | US | disclosed |