Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1034082 | 0.75 | SPHK1 (0.43) | KMT2AALDH1A1SMN1; SMN2RAB9AGAA | |
| SCHEMBL14738426 | 0.75 | SPHK1 (0.43) | KMT2AALDH1A1SMN1; SMN2RAB9AGAA | |
| SCHEMBL1031622 | 0.73 | GRM2 (0.48) | FAAHKMT2AMEN1 | |
| SCHEMBL3743415 | 0.71 | GRM2 (0.45) | KMT2AALDH1A1RAB9AGAAKDM4E | |
| SCHEMBL3164544 | 0.70 | SMN1; SMN2 (0.32) | SMN1; SMN2KDM4E | |
| SCHEMBL23507491 | 0.69 | FAAH (0.60) | FAAHKMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL3173400 | 0.68 | SPHK1 (0.45) | FAAHSMN1; SMN2RAB9AHTT | |
| SCHEMBL8045499 | 0.68 | FAAH (0.50) | FAAHKMT2ARAB9AMEN1PDE10A | |
| SCHEMBL15007429 | 0.67 | SPHK1 (0.46) | KMT2AMEN1TSHR | |
| Hydrochloric Acid SCHEMBL8045138 | 0.67 | FAAH (0.49) | FAAHKMT2ARAB9AMEN1PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121280-A | Azabicyclic rotomase inhibitors | PFIZER INC. (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0947506-A1 | 2-Aza-bicyclo[2.2.1]heptane derivatives and their use as rotamase inhibitors | Pfizer Products Inc. (US) | 1999-10-06 | — | — | EP | disclosed |