Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 3/20 | 0.36 |
| ▸ | PRKACG | P22612 | 3/20 | 0.36 |
| ▸ | PRKACB | P22694 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8045138 | 0.99 | FAAH (0.49) | FAAHKMT2AHRH4JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL6979904 | 0.99 | FAAH (0.49) | FAAHKMT2AHRH4JAK2JAK1 | |
| SCHEMBL23507491 | 0.79 | FAAH (0.60) | FAAHKMT2AMEN1 | |
| SCHEMBL7654968 | 0.78 | FAAH (0.60) | FAAH | |
| SCHEMBL5824541 | 0.75 | CXCR4 (0.65) | KMT2ACXCR4MEN1RAB9A | |
| SCHEMBL31669240 | 0.75 | CXCR4 (0.65) | KMT2ACXCR4MEN1RAB9A | |
| Hydrochloric Acid SCHEMBL4221712 | 0.75 | DRD4 (0.50) | FAAHOPRK1PDE10A | |
| SCHEMBL5945358 | 0.74 | SLC2A1 (0.46) | FAAHNPC1RAB9AEGFRERBB2 | |
| Hydrochloric Acid SCHEMBL28987734 | 0.74 | CXCR4 (0.63) | KMT2ACXCR4MEN1RAB9A | |
| SCHEMBL6977509 | 0.73 | FAAH (0.51) | FAAHKMT2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121280-A | Azabicyclic rotomase inhibitors | PFIZER INC. (US) | 2000-09-19 | — | — | US | disclosed |
| EP-0947506-A1 | 2-Aza-bicyclo[2.2.1]heptane derivatives and their use as rotamase inhibitors | Pfizer Products Inc. (US) | 1999-10-06 | — | — | EP | disclosed |