Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049333 | 0.99 | EDNRA (0.50) | EDNRAALDH1A1HPGDKDM4EGAA | |
| SCHEMBL8052404 | 0.95 | EDNRA (0.46) | EDNRAALDH1A1HPGDKDM4EGAA | |
| SCHEMBL8590715 | 0.94 | EDNRA (0.58) | EDNRAALDH1A1HPGDKDM4EGAA | |
| SCHEMBL3838490 | 0.93 | EDNRA (0.58) | EDNRAALDH1A1HPGDKDM4EGAA | |
| SCHEMBL3835089 | 0.89 | EDNRA (0.53) | EDNRAALDH1A1HPGDKDM4EGAA | |
| SCHEMBL8046894 | 0.85 | EDNRA (0.57) | EDNRAALDH1A1HPGDKDM4ENPSR1 | |
| SCHEMBL8046639 | 0.84 | EDNRA (0.65) | EDNRAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL7496900 | 0.83 | EDNRA (0.64) | EDNRAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL8432726 | 0.82 | EDNRA (0.54) | EDNRAALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL7496869 | 0.81 | EDNRA (0.66) | EDNRAALDH1A1HPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143774-A | DRUGS AS HYPOTENSIVE AGENTS | HOECHST MARION ROUSSEL (FR) | 2000-11-07 | — | — | US | disclosed |