Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044206 | 1.00 | AURKA (0.37) | AURKAKDRAURKBCDK5CDK5R1 | |
| SCHEMBL8046738 | 0.79 | HDAC1 (0.33) | AURKAKDRAURKBCDK5CDK5R1 | |
| SCHEMBL8052434 | 0.79 | HDAC1 (0.33) | AURKAKDRAURKBCDK5CDK5R1 | |
| SCHEMBL8040097 | 0.77 | KMT2A (0.47) | AURKAKDRAURKBCDK5CDK5R1 | |
| SCHEMBL8045597 | 0.77 | KMT2A (0.47) | AURKAKDRAURKBCDK5CDK5R1 | |
| SCHEMBL8049240 | 0.76 | AURKA (0.36) | AURKAKDRAURKBCDK5CDK5R1 | |
| SCHEMBL8052442 | 0.74 | AURKA (0.38) | AURKAKDRAURKBCDK5CDK5R1 | |
| SCHEMBL8040840 | 0.67 | POLB (0.34) | HDAC1HDAC8MEN1KMT2A | |
| SCHEMBL10352909 | 0.65 | LMNA (0.32) | MAPTHDAC1HDAC8HTTSMN1; SMN2 | |
| SCHEMBL8052878 | 0.65 | POLB (0.35) | HDAC1HDAC8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009085978-A1 | BRIDGED CARBOCYCLIC OXIME HEPATITIS C VIRUS SERINE PROTEASE INHIBITORS | ENANTA PHARCEUTICALS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |