Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.67 |
| ▸ | BLM | P54132 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.63 |
| ▸ | NOS2 | P35228 | 6/20 | 0.46 |
| ▸ | NOS1 | P29475 | 5/20 | 0.46 |
| ▸ | NOS3 | P29474 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.46 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamine SCHEMBL19691979 | 1.00 | GSR (0.67) | GSRBLMKMT2AALOX15PMP22 | |
| Glutamine SCHEMBL5461649 | 0.93 | GSR (0.77) | GSRBLMKMT2AALOX15PMP22 | |
| Glutamine SCHEMBL1812362 | 0.93 | GSR (0.77) | GSRBLMKMT2AALOX15PMP22 | |
| Glutamine SCHEMBL28030897 | 0.93 | GSR (0.77) | GSRBLMKMT2AALOX15PMP22 | |
| Glutamine SCHEMBL1347541 | 0.93 | GSR (0.77) | GSRBLMKMT2AALOX15PMP22 | |
| Glutamine SCHEMBL2143276 | 0.93 | GSR (0.77) | GSRBLMKMT2AALOX15PMP22 | |
| Glutamine SCHEMBL12468749 | 0.93 | GSR (0.77) | GSRBLMKMT2AALOX15PMP22 | |
| Glutamine SCHEMBL19743900 | 0.91 | GSR (0.74) | GSRBLMKMT2AALOX15PMP22 | |
| Glutamine SCHEMBL29022149 | 0.91 | GSR (0.74) | GSRBLMKMT2AALOX15PMP22 | |
| Glutamine SCHEMBL14485689 | 0.91 | GSR (0.74) | GSRBLMKMT2AALOX15PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6027920-A | DNA CASSETTE FOR EXPRESSION AND SECRETION OF AN AMINO ACID, POLYPEPTIDE OR PROTEIN IN A CORYNEBACTERIUM HOST, INCLUDES A SEQUENCE ENCODING THE SIGNAL SEQUENCE OF THE PROTEIN PS1 OR PS2, THE AT TO ENSURE SECRETION AFTER TRANSLATION | ORSAN (FR) | 2000-02-22 | — | — | US | disclosed |
| EP-0551506-A1 | SYSTEM FOR PROTEIN EXPRESSION AND SECRETION ESPECIALLY IN CORYNEBACTERIA | ORSAN (FR) | 1993-07-21 | — | — | EP | disclosed |
| WO-1993003158-A1 | SYSTEM FOR PROTEIN EXPRESSION AND SECRETION ESPECIALLY IN CORYNEBACTERIA | ORSAN (FR) | 1993-02-18 | — | — | WO | disclosed |