Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515850 | 0.82 | HDAC4 (0.45) | HDAC4HDAC6HTTKDM4EMITF | |
| SCHEMBL22445500 | 0.79 | HDAC6 (0.43) | HDAC4HDAC6HTTKDM4EMITF | |
| SCHEMBL8052668 | 0.77 | HDAC4 (0.50) | HDAC4HDAC6HTTALDH1A1GAA | |
| SCHEMBL1515840 | 0.76 | LMNA (0.54) | HTTALDH1A1ACHELMNAL3MBTL1 | |
| SCHEMBL4440407 | 0.75 | KDM4E (0.43) | HDAC4HDAC6KDM4EALDH1A1LMNA | |
| SCHEMBL1399311 | 0.74 | TDP1 (0.56) | HDAC4HDAC6HTTKDM4EALDH1A1 | |
| SCHEMBL16929957 | 0.72 | HDAC1 (0.52) | HDAC6HTTKDM4EALDH1A1LMNA | |
| SCHEMBL1707313 | 0.72 | TAAR1 (0.46) | HDAC4HDAC6 | |
| SCHEMBL29066070 | 0.71 | TSHR (0.65) | ALDH1A1LMNAGAA | |
| SCHEMBL20551648 | 0.70 | HDAC4 (0.42) | HDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | disclosed |
| US-5637771-A | Compound useful for lowering cholesterol | HOFFMANN-LA ROCHE INC. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5574071-A | ADMINISTERING PHENYLALKYLAMINO KETONES | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5495048-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| EP-0636367-A1 | Use of phenylalkylamines for producing cholesterol lowering agents | F. HOFFMANN-LA ROCHE AG (CH) | 1995-02-01 | — | — | EP | disclosed |