Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515850 | 0.88 | HDAC4 (0.45) | HDAC6HDAC4KDM4EMITFALDH1A1 | |
| SCHEMBL18912182 | 0.84 | PARP1 (0.43) | HDAC6HDAC4HDAC1DAOALDH1A1 | |
| SCHEMBL22607853 | 0.82 | HPGD (0.41) | HDAC6HDAC4HDAC1ALDH1A1PTGS1 | |
| SCHEMBL4440407 | 0.81 | KDM4E (0.43) | HDAC6HDAC4HDAC1KDM4EALDH1A1 | |
| SCHEMBL8045889 | 0.79 | HDAC4 (0.45) | HDAC6HDAC4KDM4EMITFALDH1A1 | |
| SCHEMBL1399311 | 0.79 | TDP1 (0.56) | HDAC6HDAC4KDM4EALDH1A1HTT | |
| SCHEMBL30965121 | 0.79 | RAB9A (0.43) | HDAC6HDAC4KDM4EALDH1A1PTGS1 | |
| SCHEMBL19181646 | 0.79 | SKP2 (0.41) | HDAC6HDAC4KDM4EALDH1A1PTGS1 | |
| SCHEMBL1555409 | 0.78 | ALDH1A1 (0.53) | HDAC6HDAC1ALDH1A1KMT2A | |
| SCHEMBL8064820 | 0.77 | HDAC4 (0.49) | HDAC6HDAC4POLBAPEX1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12351577-B2 | Inhibiting cyclic AMP-responsive element-binding protein (CREB) | FORMA THERAPEUTICS, INC. (US) | 2025-07-08 | — | — | US | disclosed |
| US-20250188079-A1 | INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) | FORMA THERAPEUTICS, INC. | 2025-06-12 | — | — | US | disclosed |
| US-20220213089-A1 | INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) | FORMA THERAPEUTICS, INC. | 2022-07-07 | — | — | US | disclosed |
| US-20220213089-A1 | INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) | FORMA THERAPEUTICS, INC. | 2022-07-07 | — | — | US | disclosed |
| EP-3937940-A1 | INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) | Forma Therapeutics, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |
| WO-2020190791-A1 | INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) | FORMA THERAPEUTICS, INC. (US) | 2020-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250188079-A1 | INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) | CREBBP, CREB1, EP300 | HDAC6 299/4885HDAC4 137/4885HDAC1 25/4885 |
| US-12351577-B2 | Inhibiting cyclic AMP-responsive element-binding protein (CREB) | CREBBP, CREB1, EP300 | HDAC6 299/4885HDAC4 137/4885HDAC1 25/4885 |
| US-20220213089-A1 | INHIBITING CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN (CREB) | CREBBP, CREB1, EP300 | HDAC6 299/4885HDAC4 137/4885HDAC1 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.