Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cadaverine Tartrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | PGD | P52209 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butanedione SCHEMBL52101 | 1.00 | TSHR (0.50) | TSHRTHPOTP53NFKB1CYP2C19 | |
| SCHEMBL1397720 | 0.89 | TSHR (0.62) | TSHRTP53NFKB1CYP2C19ALDH1A1 | |
| SCHEMBL29232003 | 0.89 | TSHR (0.62) | TSHRTP53NFKB1CYP2C19ALDH1A1 | |
| SCHEMBL9862728 | 0.89 | TSHR (0.62) | TSHRTP53NFKB1CYP2C19ALDH1A1 | |
| SCHEMBL14742965 | 0.87 | TSHR (0.59) | TSHRTP53NFKB1CYP2C19PGD | |
| SCHEMBL305067 | 0.85 | TSHR (0.50) | TSHRTP53NFKB1CYP2C19ALDH1A1 | |
| Cadaverine Tartrate SCHEMBL19692567 | 0.85 | TSHR (0.50) | TSHRTP53NFKB1CYP2C19ALDH1A1 | |
| SCHEMBL8683125 | 0.85 | TSHR (0.50) | TSHRTP53NFKB1CYP2C19ALDH1A1 | |
| SCHEMBL1580351 | 0.84 | TSHR (0.56) | TSHRTP53NFKB1CYP2C19PGD | |
| SCHEMBL7992773 | 0.84 | TSHR (0.56) | TSHRTP53NFKB1CYP2C19PGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130257-A | Compositions of enantiomeric diacyl tartaric anhydrides and preparation thereof | QUEST INTERNATIONAL B.V. (NL) | 2000-10-10 | — | — | US | disclosed |
| EP-0827494-B1 | COMPOSITIONS OF ENANTIOMERIC DIACYL TARTARIC ANHYDRIDES AND PREPARATION THEREOF | QUEST INT (NL) | 2000-03-08 | — | — | EP | disclosed |
| EP-0827494-A1 | COMPOSITIONS OF ENANTIOMERIC DIACYL TARTARIC ANHYDRIDES AND PREPARATION THEREOF | QUEST INTERNATIONAL B.V. (NL) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996035658-A1 | COMPOSITIONS OF ENANTIOMERIC DIACYL TARTARIC ANHYDRIDES AND PREPARATION THEREOF | QUEST INTERNATIONAL B.V. (NL) | 1996-11-14 | — | — | WO | disclosed |