SCHEMBL8046855

SCHEMBL8046855

C=CC(=O)NC(C)(C)C(=O)NCCC[Si](F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ZDHHC20 Q5W0Z9 1/20 0.42
ZDHHC2 Q9UIJ5 1/20 0.42
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
EPHX1 P07099 2/20 0.36
GAA P10253 1/20 0.35
ALDH1A1 P00352 3/20 0.34
POLB P06746 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
CA12 O43570 1/20 0.31
CA2 P00918 1/20 0.31
CA3 P07451 1/20 0.31
CA4 P22748 1/20 0.31
CA6 P23280 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9248885 0.84 ZDHHC20 (0.44) ZDHHC20ZDHHC2MEN1KMT2AEPHX1
SCHEMBL30780867 0.83 ZDHHC20 (0.59) ZDHHC20ZDHHC2EPHX1GAA
SCHEMBL31560040 0.81 ZDHHC20 (0.67) ZDHHC20ZDHHC2MEN1KMT2AEPHX1
SCHEMBL30780820 0.81 ZDHHC20 (0.67) ZDHHC20ZDHHC2MEN1KMT2AEPHX1
SCHEMBL30780841 0.81 ZDHHC20 (0.67) ZDHHC20ZDHHC2MEN1KMT2AEPHX1
SCHEMBL19963646 0.81 ZDHHC20 (0.67) ZDHHC20ZDHHC2MEN1KMT2AEPHX1
SCHEMBL8342102 0.81 ZDHHC20 (0.67) ZDHHC20ZDHHC2MEN1KMT2AEPHX1
SCHEMBL19951570 0.80 ZDHHC20 (0.44) ZDHHC20ZDHHC2GAAALDH1A1CYP3A4
SCHEMBL23409931 0.79 ZDHHC20 (0.41) ZDHHC20ZDHHC2MEN1KMT2AEPHX1
SCHEMBL19951583 0.79 ADRA1A (0.49) ZDHHC20ZDHHC2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0421643-B1 Radiation-curable silicone elastomers and pressure sensitive adhesives MINNESOTA MINING & MFG (US) 2000-12-27 EP disclosed
US-5475124-A Fluorosilane compounds useful as terminating agents in anionic siloxane polymerization MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1995-12-12 US disclosed
US-5314748-A Radiation-curable silicone elastomers and pressure sensitive adhesives MINNESOTA MINING & MANUFACTURING COMPANY (US) 1994-05-24 US disclosed
US-5237082-A Amine subsituted fluorosilanes MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1993-08-17 US disclosed
US-5091483-A Controllability and stability of rapidly-cured telechelic polymers containing ethylenic, amido, ester and/or urea groups MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1992-02-25 US disclosed
EP-0421643-A2 Radiation-curable silicone elastomers and pressure sensitive adhesives MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1991-04-10 EP disclosed