SCHEMBL8047223

SCHEMBL8047223

CNC(=O)Nc1ccc(CCO)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.56
HRH3 Q9Y5N1 1/20 0.54
KMT2A Q03164 2/20 0.50
SAE1 Q9UBE0 3/20 0.49
UBA2 Q9UBT2 3/20 0.49
CYP4F2 P78329 1/20 0.49
CYP4A11 Q02928 1/20 0.49
CNR1 P21554 2/20 0.47
POLB P06746 1/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.45
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
PIK3CA P42336 1/20 0.44
MTOR P42345 1/20 0.44
PIK3CG P48736 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14052828 0.88 HRH3 (0.61) HRH3KMT2ASAE1UBA2CYP4F2
SCHEMBL8866937 0.85 ALDH1A1 (0.56) ALDH1A1HRH3KMT2ASAE1UBA2
SCHEMBL12678507 0.85 PLK1 (0.58) ALDH1A1HRH3KMT2ASAE1UBA2
SCHEMBL16919653 0.85 ALDH1A1 (0.60) ALDH1A1HRH3KMT2ASAE1UBA2
SCHEMBL821704 0.84 SAE1 (0.65) ALDH1A1HRH3KMT2ASAE1UBA2
SCHEMBL27639092 0.82 CA12 (0.64) ALDH1A1KMT2APOLBNPC1RAB9A
SCHEMBL8868038 0.82 CNR1 (0.53) ALDH1A1HRH3CYP4F2CYP4A11CNR1
SCHEMBL10155599 0.82 ALDH1A1 (0.78) ALDH1A1KMT2ASAE1UBA2POLB
SCHEMBL8868654 0.81 EPHX1 (0.63) HRH3KMT2ANPC1RAB9A
SCHEMBL7472737 0.81 ALDH1A1 (0.60) ALDH1A1HRH3KMT2ASAE1UBA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0991632-A1 NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES Astra Aktiebolag (SE) 2000-04-12 EP disclosed
WO-1998057941-A1 NEW THIAZOLIDINEDIONE, OXAZOLIDINEDIONE AND OXADIAZOLIDINEDIONE DERIVATIVES ASTRA AKTIEBOLAG (SE) 1998-12-23 WO disclosed
US-5686484-A ANTHELMINTICS, ACARICIDES, INSECTICIDES SANKYO CO., LTD. (JP) 1997-11-11 US disclosed