Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TLR5 | O60602 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051302 | 0.83 | ATM (0.48) | SMN1; SMN2ATMTSHRKDM4EHSD17B10 | |
| SCHEMBL8041924 | 0.82 | TSHR (0.66) | SMN1; SMN2TSHRKDM4EHSD17B10MEN1 | |
| SCHEMBL8032636 | 0.82 | ATM (0.47) | SMN1; SMN2ATMTSHRMEN1KMT2A | |
| SCHEMBL8047373 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2ATMTSHRKDM4EHSD17B10 | |
| SCHEMBL8042581 | 0.80 | ATM (0.47) | SMN1; SMN2ATMTSHRMEN1KMT2A | |
| SCHEMBL8051092 | 0.79 | ATM (0.47) | SMN1; SMN2ATMTSHROPRK1MEN1 | |
| SCHEMBL8719307 | 0.79 | TP53 (0.48) | SMN1; SMN2TSHRKDM4EHSD17B10MEN1 | |
| SCHEMBL8042081 | 0.78 | TSHR (0.44) | SMN1; SMN2TSHRKDM4EHSD17B10MEN1 | |
| SCHEMBL8050081 | 0.78 | TSHR (0.48) | SMN1; SMN2ATMTSHRL3MBTL1HTT | |
| SCHEMBL8052238 | 0.77 | POLB (0.45) | SMN1; SMN2ATMTSHRKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |