Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050081 | 0.92 | TSHR (0.48) | ATMSMN1; SMN2SIRT2HTTLMNA | |
| SCHEMBL8051302 | 0.87 | ATM (0.48) | ATMSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL8044252 | 0.87 | ATM (0.41) | ATMSMN1; SMN2HTTMAPK1TSHR | |
| SCHEMBL8047690 | 0.82 | SMN1; SMN2 (0.50) | ATMSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL8049124 | 0.81 | TSHR (0.60) | SMN1; SMN2HTTMAPTMAPK1TSHR | |
| SCHEMBL8033946 | 0.81 | ATM (0.45) | ATMSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL8047373 | 0.79 | SMN1; SMN2 (0.47) | ATMSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL8709945 | 0.79 | ALDH1A1 (0.52) | SMN1; SMN2RAB9ANPC1HTTLMNA | |
| SCHEMBL8051092 | 0.78 | ATM (0.47) | ATMSMN1; SMN2RAB9ANPC1HTT | |
| SCHEMBL8034048 | 0.78 | KDM4E (0.53) | SMN1; SMN2RAB9ANPC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |