Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | HPGD | P15428 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044866 | 0.77 | GRK6 (0.62) | HSD17B10GABRA5GABRB2KDM4EALDH1A1 | |
| SCHEMBL8042767 | 0.77 | HSD17B10 (0.45) | HSD17B10GABRA5GABRB2EGLN1KDM4E | |
| SCHEMBL8042478 | 0.75 | GAA (0.49) | HSD17B10GABRA5GABRB2KDM4EALDH1A1 | |
| SCHEMBL9332045 | 0.75 | HSD17B10 (0.56) | HSD17B10GABRA5GABRB2EGLN1KDM4E | |
| SCHEMBL10361187 | 0.74 | HSD17B10 (0.59) | HSD17B10GABRA5GABRB2EGLN1KDM4E | |
| SCHEMBL856450 | 0.72 | GABRA5 (0.61) | POLBHSD17B10GABRA5GABRB2KDM4E | |
| SCHEMBL8033980 | 0.72 | HSD17B10 (0.43) | POLBHSD17B10GABRA5GABRB2EGLN1 | |
| SCHEMBL9332036 | 0.71 | HSD17B10 (0.56) | HSD17B10GABRA5GABRB2EGLN1KDM4E | |
| SCHEMBL8043845 | 0.71 | HSD17B10 (0.45) | HSD17B10GABRA5GABRB2EGLN1KDM4E | |
| SCHEMBL8048752 | 0.71 | HSD17B10 (0.42) | HSD17B10GABRA5GABRB2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |