Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050333 | 0.91 | GABRA5 (0.40) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL8042878 | 0.90 | HSD17B10 (0.42) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL8045034 | 0.89 | RAB9A (0.41) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL8033980 | 0.86 | HSD17B10 (0.43) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL8042264 | 0.85 | ALDH1A1 (0.41) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL8044346 | 0.84 | LMNA (0.41) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL8044611 | 0.83 | LMNA (0.39) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL8044114 | 0.82 | HSD17B10 (0.40) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL8044613 | 0.79 | ALDH1A1 (0.38) | HSD17B10GABRA5GABRB2ALDH1A1KDM4E | |
| SCHEMBL8043900 | 0.76 | SMN1; SMN2 (0.36) | ALDH1A1KDM4ELMNAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |