Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8065335 | 0.98 | TSHR (0.44) | TSHRGPR84FAAHTRPV1TOP1 | |
| SCHEMBL7613427 | 0.87 | GPR84 (0.38) | TSHRGPR84FAAHTRPV1FFAR1 | |
| SCHEMBL7933234 | 0.85 | GPR84 (0.37) | TSHRGPR84TOP1ALDH1A1 | |
| SCHEMBL7613804 | 0.85 | HIF1A (0.38) | TSHRGPR84FAAHTRPV1 | |
| SCHEMBL5354813 | 0.85 | GPR84 (0.52) | GPR84ALDH1A1FFAR1FFAR4 | |
| SCHEMBL30525712 | 0.85 | TOP1 (0.59) | GPR84FAAHTOP1FFAR1FFAR4 | |
| SCHEMBL23249652 | 0.83 | GPR84 (0.62) | TSHRGPR84ALDH1A1FFAR1FFAR4 | |
| SCHEMBL8133996 | 0.83 | GPR84 (0.62) | TSHRGPR84ALDH1A1FFAR1FFAR4 | |
| SCHEMBL5878852 | 0.83 | GPR84 (0.62) | TSHRGPR84ALDH1A1FFAR1FFAR4 | |
| SCHEMBL630334 | 0.83 | GPR84 (0.62) | TSHRGPR84ALDH1A1FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047677-A2 | Process for the preparation of derivatives of 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid | BRACCO S.p.A. (IT) | 2000-11-02 | — | — | EP | claimed |
| WO-1999035133-A2 | 1,4,7,10-TETRAAZACYCLODODECANE-1,4-DIACETIC ACID DERIVATIVES AS CHELATING AGENTS | BRACCO S.P.A. (IT) | 1999-07-15 | — | — | WO | claimed |
| EP-1047677-A2 | Process for the preparation of derivatives of 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid | BRACCO S.p.A. (IT) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999035133-A2 | 1,4,7,10-TETRAAZACYCLODODECANE-1,4-DIACETIC ACID DERIVATIVES AS CHELATING AGENTS | BRACCO S.P.A. (IT) | 1999-07-15 | — | — | WO | disclosed |