Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046515 | 0.83 | POLB (0.45) | ALDH1A1MAPTSMN1; SMN2NPSR1TSHR | |
| SCHEMBL8044444 | 0.83 | ALDH1A1 (0.44) | ALDH1A1MAPTSMN1; SMN2NPSR1TSHR | |
| SCHEMBL8046724 | 0.83 | ALDH1A1 (0.40) | ALDH1A1MAPTSMN1; SMN2NPSR1TSHR | |
| SCHEMBL8043646 | 0.82 | ALDH1A1 (0.54) | ALDH1A1MAPTSMN1; SMN2NPSR1TSHR | |
| SCHEMBL8043896 | 0.80 | SMN1; SMN2 (0.43) | ALDH1A1MAPTSMN1; SMN2NPSR1TSHR | |
| SCHEMBL8046126 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MAPTSMN1; SMN2NPSR1TSHR | |
| SCHEMBL8045990 | 0.78 | ALDH1A1 (0.42) | ALDH1A1MAPTSMN1; SMN2NPSR1TSHR | |
| SCHEMBL8043685 | 0.78 | ALDH1A1 (0.42) | ALDH1A1MAPTSMN1; SMN2NPSR1TSHR | |
| SCHEMBL8043869 | 0.78 | MAPT (0.42) | ALDH1A1MAPTSMN1; SMN2NPSR1TSHR | |
| SCHEMBL8052209 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MAPTSMN1; SMN2NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |