Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.57 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8035863 | 0.90 | NAMPT (0.53) | NAMPTHDAC3HDAC1HTR1AHTR1D | |
| SCHEMBL8045257 | 0.87 | NAMPT (0.55) | NAMPTHDAC3HDAC1HTR1AHTR1D | |
| SCHEMBL8046351 | 0.86 | NPC1 (0.51) | NAMPTALDH1A1HDAC3HDAC1DRD2 | |
| SCHEMBL8035576 | 0.85 | HPGD (0.47) | NAMPTHDAC3HDAC1HTR1AHTR1D | |
| Hydrochloric Acid SCHEMBL8152540 | 0.85 | NPC1 (0.50) | NAMPTALDH1A1HDAC3HDAC1DRD2 | |
| SCHEMBL8035856 | 0.85 | NAMPT (0.50) | NAMPTALDH1A1HDAC3HDAC1DRD2 | |
| SCHEMBL8045277 | 0.83 | NPC1 (0.51) | NAMPTALDH1A1HDAC3HDAC1HTR1A | |
| SCHEMBL8050562 | 0.83 | NAMPT (0.57) | NAMPTDRD2 | |
| SCHEMBL8045463 | 0.83 | NAMPT (0.57) | NAMPTHDAC3DRD2DRD3HTR1A | |
| SCHEMBL8655180 | 0.82 | HDAC3 (0.52) | HDAC3HDAC1DRD2ADRA1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679649-B1 | 2,3-Dihydrobenzofuran Derivatives | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | claimed |
| EP-0679649-B1 | 2,3-Dihydrobenzofuran Derivatives | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | disclosed |
| EP-0679649-A1 | 2,3-DIHYDROBENZOFURAN DERIVATIVE | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-11-02 | — | — | EP | disclosed |