Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CTSK | P43235 | 3/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | CPA1 | P15085 | 2/20 | 0.47 |
| ▸ | CPB1 | P15086 | 1/20 | 0.47 |
| ▸ | CPA3 | P15088 | 1/20 | 0.47 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355706 | 1.00 | HSD17B10 (0.52) | HSD17B10ALDH1A1CTSKCTSBCPA1 | |
| SCHEMBL27556474 | 0.89 | SLC15A1 (0.58) | HSD17B10ALDH1A1CTSKCTSBCTSS | |
| SCHEMBL27556472 | 0.89 | SLC15A1 (0.58) | HSD17B10ALDH1A1CTSKCTSBCTSS | |
| SCHEMBL2571746 | 0.87 | CPA1 (0.56) | ALDH1A1CPA1CPB1CPA3CPB2 | |
| SCHEMBL6576006 | 0.87 | HSD17B10 (0.52) | HSD17B10ALDH1A1CTSKCTSBCTSS | |
| SCHEMBL8053077 | 0.83 | HSD17B10 (0.52) | HSD17B10ALDH1A1CTSKCTSBCTSS | |
| SCHEMBL8053081 | 0.83 | HSD17B10 (0.52) | HSD17B10ALDH1A1CTSKCTSBCTSS | |
| SCHEMBL8038393 | 0.83 | MAPT (0.48) | HSD17B10ALDH1A1CTSKCTSBSLC15A1 | |
| SCHEMBL6447818 | 0.83 | MAPT (0.48) | HSD17B10ALDH1A1CTSKCTSBSLC15A1 | |
| SCHEMBL9807076 | 0.82 | HTR2A (0.50) | ALDH1A1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124329-A | AN ENZYME INHIBITOR FOR THE TREATMENT OR PROPHYLAXIS OF TISSUE BREAKDOWN, FOR EXAMPLE RHEUMATOID ARTHRITIS, OSTEOPOROSIS, PERIODONTITIS, GINGIVITIS, CORNEAL EPIDERMAL OR GASTRIC ULCERATION, AND TUMOR, MULTIPLE SCLEROSIS | BRITISH BIOTECH PHARMACEUTICALS LTD. (GB) | 2000-09-26 | — | — | US | disclosed |
| EP-0621270-B1 | Piperazine derivatives as collagenase inhibitors | SANKYO CO (JP) | 2000-04-12 | — | — | EP | disclosed |
| US-5962529-A | OSTEOPOROSIS; RHEUMATIC DISORDERS; ORAL DISEASES; ANTIULCER AGENTS; ANTITUMOR AGENTS; ANTIINFLAMMATORY AGENTS; SKIN DISORDERS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-10-05 | — | — | US | disclosed |
| US-5643908-A | ANGIOGENESIS INHIBITOR, ANTITUMOR | SANKYO COMPANY, LIMITED (JP) | 1997-07-01 | — | — | US | disclosed |
| CN-1151157-A | Metalloproteinase inhibitors | BRITISH BIOTECH PHARM (GB) | 1997-06-04 | — | — | CN | disclosed |
| EP-0766664-A2 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1997-04-09 | — | — | EP | disclosed |
| WO-1995035275-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-12-28 | — | — | WO | disclosed |
| EP-0621270-A1 | COLLAGENASE INHIBITOR | SANKYO COMPANY LIMITED (JP) | 1994-10-26 | — | — | EP | disclosed |