SCHEMBL6576006

SCHEMBL6576006

COC(=O)CC(CC(C)C)C(=O)OCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.52
CTSK P43235 4/20 0.49
ABCB1 P08183 1/20 0.49
SLC15A1 P46059 1/20 0.49
CTSB P07858 2/20 0.48
REN P00797 1/20 0.47
MMP1 P03956 2/20 0.47
CTSS P25774 2/20 0.46
ALDH1A1 P00352 1/20 0.46
CTSL P07711 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27556474 0.91 SLC15A1 (0.58) HSD17B10CTSKSLC15A1CTSBCTSS
SCHEMBL27556472 0.91 SLC15A1 (0.58) HSD17B10CTSKSLC15A1CTSBCTSS
SCHEMBL8048833 0.87 HSD17B10 (0.52) HSD17B10CTSKSLC15A1CTSBCTSS
SCHEMBL7355706 0.87 HSD17B10 (0.52) HSD17B10CTSKSLC15A1CTSBCTSS
SCHEMBL9574213 0.85 ABCB1 (0.57) ABCB1SLC15A1CTSBALDH1A1
SCHEMBL8038393 0.85 MAPT (0.48) HSD17B10CTSKSLC15A1CTSBALDH1A1
SCHEMBL6447818 0.85 MAPT (0.48) HSD17B10CTSKSLC15A1CTSBALDH1A1
SCHEMBL8216230 0.83 SLC15A1 (0.47) HSD17B10CTSKSLC15A1CTSBCTSS
SCHEMBL8216233 0.83 SLC15A1 (0.47) HSD17B10CTSKSLC15A1CTSBCTSS
SCHEMBL19996989 0.82 SLC15A1 (0.65) HSD17B10CTSKSLC15A1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0558648-B1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY RICHARD E (US) 2004-04-28 EP disclosed
EP-0663823-B1 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS GLYCOMED INC (US) 2000-11-22 EP disclosed
US-5892112-A ACYLATION OF AMINO ACIDS WITH ANHYDRIDES OR CARBOXY GROUPS, AMIDATION WITH AMINE AND CONVERSION OF ACID OR ESTER TO HYDROXAMIC ACID AND HYDROLYSIS GLYCOMED INCORPORATED (US) 1999-04-06 US disclosed
US-5773438-A SKIN DISORDERS, RESTENOSIS, RHEUMATIC ARTHRITIS, WOUND HEALING AGENTS, ANGIOGENESIS, SHOCK GLYCOMED INCORPORATED (US) 1998-06-30 US disclosed
EP-0558681-B1 TREATMENT FOR TISSUE ULCERATION UNIV FLORIDA (US) 1998-04-08 EP disclosed
US-5696147-A CONTROLLING GROWTH OF TUMORS AND NEOVASCULAR GLAUCOMAS GLYCOMED, INC. (US) 1997-12-09 US disclosed
EP-0558635-B1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GLYCOMED INC (US) 1997-09-10 EP disclosed
EP-0692931-A4 SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF GLYCOMED INC (US) 1996-03-20 EP disclosed
EP-0690841-A4 SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF GLYCOMED INC (US) 1996-03-13 EP disclosed
EP-0692931-A1 SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF GLYCOMED INCORPORATED (US) 1996-01-24 EP disclosed
US-5270326-A Administering inhibitor of mammalian matrix metalloprotease UNIVERSITY OF FLORIDA (US) 1993-12-14 US disclosed
US-5268384-A Containing amide groups GLYCOMED, INC., A CA CORP 1993-12-07 US disclosed
EP-0558681-A4 TREATMENT FOR TISSUE ULCERATION 1993-11-18 EP disclosed
EP-0558681-A1 TREATMENT FOR TISSUE ULCERATION UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 1993-09-08 EP disclosed
US-5239078-A Collagenase enzyme inhibitors GLYCOMED INCORPORATED (US) 1993-08-24 US disclosed
WO-1993013741-A2 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS GLYCOMED, INC. (US) 1993-07-22 WO disclosed
US-5189178-A Preventing protein destruction GALARDY RICHARD E (US) 1993-02-23 US disclosed
US-5183900-A Matrix metalloprotease inhibitors GALARDY RICHARD E (US) 1993-02-02 US disclosed
WO-1992009282-A1 TREATMENT FOR TISSUE ULCERATION THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 1992-06-11 WO disclosed
US-5114953-A Peptides UNIVERSITY OF FLORIDA (US) 1992-05-19 US disclosed