Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 1/20 | 0.67 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 12/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 11/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 11/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13850000 | 0.97 | CHRNB4 (0.63) | CHRNB4CHRNA3OPRM1OPRK1OPRL1 | |
| SCHEMBL9837438 | 0.83 | OPRM1 (0.75) | CHRNB4CHRNA3OPRM1OPRK1OPRL1 | |
| SCHEMBL13849978 | 0.83 | CHRNB4 (0.46) | CHRNB4CHRNA3OPRM1OPRK1OPRL1 | |
| SCHEMBL8038486 | 0.80 | CHRNB4 (1.00) | CHRNB4CHRNA3OPRM1OPRK1OPRL1 | |
| SCHEMBL28667548 | 0.80 | OPRM1 (0.80) | CHRNB4CHRNA3OPRM1OPRK1OPRL1 | |
| SCHEMBL2554375 | 0.80 | OPRM1 (0.69) | CHRNB4CHRNA3OPRM1OPRK1OPRL1 | |
| SCHEMBL13849998 | 0.77 | CHRNB4 (0.94) | CHRNB4CHRNA3OPRM1OPRK1OPRL1 | |
| SCHEMBL8039238 | 0.77 | CHRNB4 (0.89) | CHRNB4CHRNA3OPRM1OPRK1OPRL1 | |
| SCHEMBL828730 | 0.76 | OPRM1 (0.61) | CHRNB4CHRNA3OPRM1OPRK1OPRL1 | |
| SCHEMBL29809539 | 0.76 | OPRM1 (0.61) | CHRNB4CHRNA3OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118326-A1 | Nicotinic Acetylcholine Receptor Modulators | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-05-07 | — | — | US | disclosed |
| US-20090118326-A1 | Nicotinic Acetylcholine Receptor Modulators | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-05-07 | — | — | US | disclosed |
| WO-2009058120-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | SRI INTERNATIONAL (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118326-A1 | Nicotinic Acetylcholine Receptor Modulators | CHRNA10, CHRNA6, CHRNA5 | CHRNB4 17/4885CHRNA3 10/4885OPRM1 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.