Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.61 |
| ▸ | OPRL1 | P41146 | 12/20 | 0.61 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.57 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29809539 | 1.00 | OPRM1 (0.61) | OPRM1OPRK1OPRL1CHRNB4CHRNA3 | |
| Ammonia Solution, Strong SCHEMBL1764239 | 0.98 | OPRM1 (0.59) | OPRM1OPRK1OPRL1CHRNB4CHRNA3 | |
| SCHEMBL15202950 | 0.91 | OPRM1 (0.55) | OPRM1OPRK1OPRL1CHRNB4CHRNA3 | |
| SCHEMBL15202972 | 0.91 | OPRM1 (0.55) | OPRM1OPRK1OPRL1CHRNB4CHRNA3 | |
| SCHEMBL4418077 | 0.91 | OPRM1 (0.55) | OPRM1OPRK1OPRL1CHRNB4CHRNA3 | |
| SCHEMBL2554375 | 0.88 | OPRM1 (0.69) | OPRM1OPRK1OPRL1CHRNB4CHRNA3 | |
| SCHEMBL10063412 | 0.87 | OPRL1 (0.77) | OPRM1OPRK1OPRL1CHRNB4CHRNA3 | |
| SCHEMBL13243418 | 0.86 | OPRM1 (0.68) | OPRM1OPRK1OPRL1 | |
| SCHEMBL1238158 | 0.86 | OPRM1 (0.62) | OPRM1OPRK1OPRL1 | |
| SCHEMBL28667548 | 0.85 | OPRM1 (0.80) | OPRM1OPRK1OPRL1CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050228023-A1 | Agonist and antagonist ligands of the nociceptin receptor | SRI INTERNATIONAL (US) | 2005-10-13 | — | — | US | claimed |
| EP-4291552-B1 | MODULATORS OF COMPLEX I | BOEHRINGER INGELHEIM INT (DE) | 2025-04-09 | — | — | EP | disclosed |
| EP-4455145-A2 | PIPERIDINYL NOCICEPTIN RECEPTOR COMPOUNDS | Astraea Therapeutics, LLC (US) | 2024-10-30 | — | — | EP | disclosed |
| US-12071403-B2 | Modulators of complex I | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-08-27 | — | — | US | disclosed |
| US-20240150285-A1 | MODULATORS OF COMPLEX I | BOEHRINGER INGELHEIM INT (DE) | 2024-05-09 | — | — | US | disclosed |
| US-20240059664-A1 | Piperidinyl Nociceptin Receptor Compounds | ASTRAEA THERAPEUTICS, LLC | 2024-02-22 | — | — | US | disclosed |
| US-RE49825-E1 | Piperidinyl nociceptin receptor compounds | ASTRAEA THERAPEUTICS, LLC (US) | 2024-02-06 | — | — | US | disclosed |
| EP-4291552-A1 | MODULATORS OF COMPLEX I | Boehringer Ingelheim International GmbH (DE) | 2023-12-20 | — | — | EP | disclosed |
| US-11827617-B2 | Piperidinyl nociceptin receptor compounds | ASTRAEA THERAPEUTICS, LLC (US) | 2023-11-28 | — | — | US | disclosed |
| US-11827617-B2 | Piperidinyl nociceptin receptor compounds | ASTRAEA THERAPEUTICS, LLC (US) | 2023-11-28 | — | — | US | disclosed |
| US-20030078419-A1 | Substituted pyrazoles | ORTHO MCNEIL PHARMACEUTICAL, INC. | 2003-04-24 | — | — | US | disclosed |
| US-20020115656-A1 | Method for treating allergies using substituted pyrazoles | BUTLER CHRISTOPHER R (US) | 2002-08-22 | — | — | US | disclosed |
| US-20020055497-A1 | Method for treating allergies using substituted pyrazoles | BUTLER CHRISTOPHER R (US) | 2002-05-09 | — | — | US | disclosed |
| EP-0714299-B1 | BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-04-24 | — | — | EP | disclosed |
| WO-2002020011-A2 | A METHOD FOR TREATING ALLERGIES USING SUBSTITUTED PYRAZOLES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-14 | — | — | WO | disclosed |
| WO-2002014315-A2 | SUBSTITUTED PYRAZOLES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-02-21 | — | — | WO | disclosed |
| US-5665719-A | Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists | MERCK & CO., INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0714299-A4 | — | — | 1996-07-10 | — | — | EP | disclosed |
| EP-0714299-A1 | BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995002405-A1 | BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228023-A1 | Agonist and antagonist ligands of the nociceptin receptor | OPRL1, OPRK1, OPRM1 | OPRM1 3/4885OPRK1 2/4885OPRL1 1/4885 |
| US-11827617-B2 | Piperidinyl nociceptin receptor compounds | OPRL1, OPRK1, OPRM1 | OPRM1 3/4885OPRK1 2/4885OPRL1 1/4885 |
| US-20030078419-A1 | Substituted pyrazoles | CTSS, CTSZ, CTSV | OPRM1 4858/4885OPRK1 4693/4885OPRL1 4813/4885 |
| US-20240150285-A1 | MODULATORS OF COMPLEX I | NDUFAB1, NDUFV1, NDUFB7 | OPRM1 1138/4885OPRK1 1930/4885OPRL1 2594/4885 |
| US-20020115656-A1 | Method for treating allergies using substituted pyrazoles | TSLP, IL33, HRH2 | OPRM1 4584/4885OPRK1 2768/4885OPRL1 3676/4885 |
| US-12071403-B2 | Modulators of complex I | NDUFAB1, NDUFV1, NDUFB7 | OPRM1 1138/4885OPRK1 1930/4885OPRL1 2594/4885 |
| US-20020055497-A1 | Method for treating allergies using substituted pyrazoles | TSLP, IL33, HRH2 | OPRM1 4584/4885OPRK1 2768/4885OPRL1 3676/4885 |
| US-20240059664-A1 | Piperidinyl Nociceptin Receptor Compounds | OPRL1, OPRK1, OPRM1 | OPRM1 3/4885OPRK1 2/4885OPRL1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.