SCHEMBL8048966

SCHEMBL8048966

N#Cc1ccc(OCc2ncc(-c3cc(Br)c(O)c(Br)c3)nn2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.41
MEN1 O00255 1/20 0.39
TTR P02766 1/20 0.39
ALB P02768 1/20 0.39
KMT2A Q03164 1/20 0.39
MAOB P27338 1/20 0.37
PTPN1 P18031 1/20 0.35
CYP19A1 P11511 2/20 0.34
CYP4F2 P78329 1/20 0.34
CYP4A11 Q02928 1/20 0.34
SPHK2 Q9NRA0 1/20 0.34
SPHK1 Q9NYA1 1/20 0.34
MMP2 P08253 2/20 0.34
MMP1 P03956 1/20 0.34
MMP3 P08254 1/20 0.34
MMP9 P14780 1/20 0.34
MMP13 P45452 1/20 0.34
PTGER4 P35408 1/20 0.34
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3247216 0.88 PTPN1 (0.38) ALDH1A1MEN1KMT2AMAOBPTPN1
SCHEMBL3240684 0.84 CRHBP (0.45) MEN1KMT2AMAOBPTPN1PTGER4
SCHEMBL3242273 0.80 MEN1 (0.38) MEN1TTRALBKMT2AMAOB
SCHEMBL3244165 0.79 KDM4E (0.37) ALDH1A1PTPN1MAPT
SCHEMBL3240204 0.79 NPC1 (0.39) ALDH1A1MEN1KMT2APTPN1RAB9A
SCHEMBL3240285 0.78 RXRB (0.43) ALDH1A1RAB9ANPC1MAPT
SCHEMBL3232605 0.78 ALDH1A1 (0.34) ALDH1A1PTPN1MAPT
SCHEMBL8006778 0.77 MAOB (0.46) ALDH1A1MEN1KMT2AMAOBPTPN1
SCHEMBL3240333 0.76 MCL1 (0.35) ALDH1A1RAB9ANPC1
SCHEMBL3237644 0.75 ALDH1A1 (0.40) ALDH1A1KMT2ARAB9ANPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090264433-A1 Compounds, Compositions and Methods Comprising Triazine Derivatives INSTITUTE FOR ONEWORLD HEALTH 2009-10-22 US disclosed
US-20090264433-A1 Compounds, Compositions and Methods Comprising Triazine Derivatives INSTITUTE FOR ONEWORLD HEALTH 2009-10-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090264433-A1 Compounds, Compositions and Methods Comprising Triazine Derivatives CFTR, PKD1, PKD2 ALDH1A1 2483/4885MEN1 2901/4885TTR 1286/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.