Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.86 |
| ▸ | LMNA | P02545 | 5/20 | 0.86 |
| ▸ | MEN1 | O00255 | 4/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.86 |
| ▸ | NPC1 | O15118 | 9/20 | 0.71 |
| ▸ | RAB9A | P51151 | 9/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.63 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.63 |
| ▸ | RELA | Q04206 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.62 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.62 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.60 |
| ▸ | BCHE | P06276 | 2/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8049008 | 1.00 | MAPT (0.86) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL7624571 | 0.89 | MAPT (0.80) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL6757890 | 0.88 | MAPT (0.75) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL6756655 | 0.85 | MAPT (0.74) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL6756656 | 0.85 | MAPT (0.74) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL6756657 | 0.85 | MAPT (0.74) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL8047996 | 0.85 | LTB4R (0.63) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL8047990 | 0.85 | LTB4R (0.63) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL9607442 | 0.83 | MEN1 (0.77) | MAPTLMNAMEN1KMT2ANPC1 | |
| SCHEMBL7822415 | 0.83 | SMN1; SMN2 (0.65) | MAPTLMNAMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127392-A | A MUSCLE RELAXANT FOR TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION; INOTROPIC AGENT | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-10-03 | — | — | US | disclosed |
| US-6046239-A | USED IN THE TREATMENT OF DISORDERS ASSOCIATED WITH SMOOTH MUSCLE CONTRACTION, VIA POTASSIUM CHANNEL AND CHLORIDE CHANNEL MODULATION SUCH AS URINARY INCONTINENCE, ASTHMA, ANGINA, PREMATURE LABOR, CONGESTIVE HEART FAILURE | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-04-04 | — | — | US | disclosed |