Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 5/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8047069 | 0.91 | CPT2 (0.46) | BRD4NR1H2CPT2CPT1ACPT1B | |
| SCHEMBL3950906 | 0.88 | ACLY (0.38) | HSP90AA1HSP90AB1ALDH1A1CPT2CPT1A | |
| SCHEMBL13663795 | 0.87 | NR1H2 (0.37) | BRD4NR1H2HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL8064460 | 0.84 | NR1H2 (0.41) | NR1H2HSP90AA1HSP90AB1ALDH1A1CPT2 | |
| SCHEMBL3954231 | 0.84 | CTSL (0.46) | BRD4NR1H2CTSLCTSBCTSS | |
| SCHEMBL8063010 | 0.83 | NR1H2 (0.41) | BRD4NR1H2HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL8062643 | 0.83 | CPT2 (0.45) | NR1H2HSP90AA1HSP90AB1ALDH1A1CPT2 | |
| SCHEMBL8063921 | 0.82 | CTSL (0.48) | BRD4NR1H2ALDH1A1CTSLCTSB | |
| SCHEMBL8063144 | 0.81 | BRD4 (0.43) | BRD4NR1H2ALDH1A1CPT2CPT1A | |
| SCHEMBL13662001 | 0.81 | F10 (0.36) | BRD4HSP90AA1HSP90AB1ALDH1A1CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026197-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-02-26 | — | — | WO | disclosed |